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My professional projects at Calico are primarily in private repos which I hope to open-source in the future. The projects largely fit into two buckets:
- Development of a robust ecosystem for working with mass spectrometry data combining a configurable Dockerized pipeline and R packages supporting the pipeline and downstream analysis.
- Approaches using genome-scale systems biology to understand regulation. See Induction Dynamics Expression Atlas and Impulse.
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My side-projects and past work can be found on my personal website. Here is a brief rundown.
I am the Director of Discovery Data science at @calico where my team turns key outputs of basic research (mechanisms and targets) into data science problems.
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Calico: @calico
- South San Francisco
- shackett.org
Highlights
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Pinned Loading
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calico/romic
calico/romic Publicromic represents high-dimensional measurements by persistently tracking features, samples, and measurements as a dataset is modified and reformatted. It provides a suite of functions that build on …
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calico/claman
calico/claman PublicCalico Lipidomics and Metabolomics (CLaM) Analysis provides a suite of functions which support data manipulation, statistical analysis and visualizations of mzrollDB files created by MAVEN.
R 2
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calico/impulse
calico/impulse PublicFit phenomenological sigmoid and impulse curves with priors to improve interpretability
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mQTL
mQTL PublicTesting how genetic variation in a cross between two parental yeast strains impacts the metabolome
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