A longitudinal genome-wide survival study to identify genetic variants associated with progression from Parkinson's disease (PD) to PD dementia (PDD)
MEGA.PDD.sh requires MEGA.PPD.PCA.R, which need subject file, longitudial visit file, genotyping file and sample plate file. MEGA.PHS.R was used to calculate polygenic hazard score for subjects, input files include genotyping file and file with Hazard ratio of SNP. The cohort clinical and genotyping and sample list data was available after approved by Brigham & Women's Hospital, please send request email to Liu Ganqiang, Ph.D. liugq3@mail.sysu.edu.cn and Scherzer, Clemens R.,M.D. cscherzer@rics.bwh.harvard.edu