Contains:

Installation:

Install homebrew
Tap this repo ( brew tap stek29/tdesktop ). Btw, after that repo would be cloned to $(brew --repo stek29/tdesktop), and you could take patches and other stuff from there.
Install all the formulas, following order in official instructions: zlib, openssl, libexif, openal-soft-td, opus, ffmpeg-td, libiconv, qt5-td (this one would be really sloooooow), gyp-td
Apply gyp.diff patch to tdesktop
If you really want to get crashpad, clone depot_tools to Libraries, and then follow official instructions starting at 'Build crashpad', but instead of /Users/user/TBuild/Libraries/gyp add /usr/local/opt/gyp-td/bin to PATH. Or you could try not to use crashpad.
If you don't want to, apply no_crashpad.diff
I also highly recommend you to disable autoupdate by adding TDESKTOP_DISABLE_AUTOUPDATE in Telegram.gyp's defines

Name		Name	Last commit message	Last commit date
Latest commit History 29 Commits
LICENSE		LICENSE
README.md		README.md
ffmpeg-td.rb		ffmpeg-td.rb
gyp-td.rb		gyp-td.rb
gyp.diff		gyp.diff
libexif.rb		libexif.rb
libiconv.rb		libiconv.rb
openal-soft-td.rb		openal-soft-td.rb
openssl.rb		openssl.rb
opus.rb		opus.rb
pkg-config.rb		pkg-config.rb
qt.sh		qt.sh
qt5-td.rb		qt5-td.rb
xz.rb		xz.rb
zlib.rb		zlib.rb