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default prior for general likelihoods #63

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stephens999 opened this issue May 4, 2017 · 1 comment
Open

default prior for general likelihoods #63

stephens999 opened this issue May 4, 2017 · 1 comment

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@stephens999
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@mengyin for general likelihoods does it make sense to have the "null-biased" prior as
default? Might be better to make it uniform? What is your experience?

@mengyin
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mengyin commented May 6, 2017

Yes I always use the "uniform" prior instead of the "null-biased" prior. It makes more sense to make the default prior "uniform".

But "null-biased prior" might still be useful in some contexts? Say when we compare singlecell data of two replicates and try finding "outlying genes", we estimate p:=count1/(count1+count2), the mode should be around 0.5 and we expect most genes to come from the "null component" (mode pointmass component).

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