Network-Based Target Prioritization and Drug Candidate Identification for Multiple Sclerosis: From Analyzing “Omics Data” to Druggability Simulations

Gene Prioritizating by PS-V2N methods(by PS-V2N.R)

This is a shortest path-based algorithm named PS-V2N (Proximity Score of Vertex to Network) which was proposed for the target identification. Here is our work pipeline:

1. work before

Before calculation，ready for one txt/csv file(such as MSPPIN_vertex.csv), first column is gene name, and the second colname is the type identification code 0, 1, and 2 (0 means groupB, 1 maens groupA, 2 means share genes); get your edges-network file ready (such as MSPPIN_edge.csv)

2. Our method could be summarized into four steps：

① Divided genes in network into subsets A and B;

② Choose gene vi from A and all genes from B;

③ Keep the edges among the selected genes in step 2) to construct the sub-network Gsub;

④ Calculate the proximity score for gene vi in Gsub.

3. Run PS-V2N.R and then you'll get a table list ordered by PS-V2N value,results are as follows: