bioSA

Introduction

The files provided here are for the paper "Multi-Resolution Sensitivity Analysis of Model of Immune Response to Helicobacter pylori Infection via Spatio-Temporal Metamodeling".

A summary of files:

• The R code for metamodel building for the 1st stage (3T) - 25D_log_Dose_norm_3T_main.R

• The R code for metamodel building for the 2nd stage (T2S10) - 25D_log_Dose_norm_T2S10_main.R

• The original datasets - M0_LP.csv, M1_LP.csv, M2_LP.csv

• The resulting metamodel fitting data for the 1st stage (3T) - M0_LP_norm_log_3T.Rdata, M1_LP_norm_log_3T.Rdata , M2_LP_norm_log_3T.Rdata

• The resulting metamodel fitting data for the 2nd stage (T2S10) - M0_LP_norm_log_T2S10.Rdata, M1_LP_norm_log_T2S10.Rdata, M2_LP_norm_log_T2S10.Rdata

• The R code for SA for the 1st stage (3T) - SA_25D_Dose_main_norm_3T.R

• The R code for SA for the 2nd stage (T2S10) - SA_25D_Dose_main_norm_T2S10_M0.R, SA_25D_Dose_main_norm_T2S10_M1.R, SA_25D_Dose_main_norm_T2S10_M2.R

• The resulting SA data for the 1st stage (3T) - SA_M0_LP_norm_log_3T.Rdata , SA_M1_LP_norm_log_3T.Rdata , SA_M2_LP_norm_log_3T.Rdata

• The resulting SA data for the 2nd stage (T2S10) is too large to be uploaded...

Other supporting files for fitting the metamodel and Monte Carlo simulation

Other supporting files for the generation of heatmaps

• Heatmaps for all parameters: M0_LP_sgn_5.png, M1_LP_sgn_5.png, M2_LP_sgn_5.png, Th17_LP_sgn_5.png, Th17_GLN_sgn_5.png