GitHub - ModelDBRepository/230888: The cannula artifact (Chandler & Hodgkin 1965)

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chandler1.ses		chandler1.ses
init.hoc		init.hoc
mosinit.hoc		mosinit.hoc
readme.html		readme.html
screenshot.png		screenshot.png
screenshot1.png		screenshot1.png
var_time_step.ses		var_time_step.ses

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<html><pre>
This is the readme for a NEURON simulator model associated with the paper:

    Chandler WK, Hodgkin AL (1965) The effect of internal sodium on
    the action potential in the presence of different internal
    anions. J Physiol 181:594-611

This model was contributede by Michael Hines who created the model in
collaboration with John Moore. NEURON is required to run this model
and is freely available at <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>

The model demonstrates the "cannula artifact" discussed in the paper
(see Fig 5 in the paper and it's corresponding linear circuit model

<img src="./screenshot1.png" alt="screenshot 1" width="550">

displayed when you run the model in this archive). The artifact makes
it appear as though you are recording an Action Potential voltage greater
than the sodium (Na+) reversal potential when this shouldn't be
possible. 

Model usage: either auto-launch from modeldb or download and extract
this archive and start with the mosinit.hoc.  For more help on starting the model see:
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>

Once the model starts it completes quickly and generates a graph:

<img src="./screenshot.png" alt="screenshot" width="550">

where the red trace shows a recorded action potential reaching 58
volts while ena=50 thus demonstrating the cannula artifact (see
figure 8 b bottom's 3mm similar AP).
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