GitHub - ModelDBRepository/263034: Evaluation of passive component of propagating AP in mossy fiber axons (Ohura & Kamiya 2018)

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Evaluation of passive component of propagating AP in mossy fiber axons (Ohura & Kamiya 2018)

modeldb.science/263034

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Name		Name	Last commit message	Last commit date
Latest commit History 3 Commits
images		images
Fig. 4G illusration.png		Fig. 4G illusration.png
Fig. 4H illusration.png		Fig. 4H illusration.png
long_(-)pulse.hoc		long_(-)pulse.hoc
long_(-)pulse.ses		long_(-)pulse.ses
mfbhh.mod		mfbhh.mod
mosinit.hoc		mosinit.hoc
passive_propagation.hoc		passive_propagation.hoc
passive_propagation.ses		passive_propagation.ses
passive_short_pulse.hoc		passive_short_pulse.hoc
passive_short_pulse.ses		passive_short_pulse.ses
propagation.hoc		propagation.hoc
propagation.ses		propagation.ses
readme.html		readme.html
short_pulse.hoc		short_pulse.hoc
short_pulse.ses		short_pulse.ses

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<html>
<p>This is the readme for the modeling in the paper:
</p>
<p>Ohura S, Kamiya H (2018) Sodium Channel-Dependent and -Independent Mechanisms Underlying Axonal Afterdepolarization at Mouse Hippocampal Mossy Fibers. eNeuro
<a href="http://dx.doi.org/10.1523/ENEURO.0254-18.2018">http://dx.doi.org/10.1523/ENEURO.0254-18.2018</a>
</p>
<p>whos model was the Hodgkin-Huxley type model of the set of sodium,
potassium, and leakage channels found in the hippocampal mossy fiber
boutons as described in
</p>
<p>Engel D, Jonas P (2005) Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron 45:405-17
<a href="http://dx.doi.org/10.1016/j.neuron.2004.12.048">http://dx.doi.org/10.1016/j.neuron.2004.12.048</a>
</p>
<p>This model was contributed by H Kamiya.
</p>
<p>Two illustrations show the simulation configuration in which sodium
and potassium conductance was omitted from the axon and the bouton
compartments shown in red.
</p>
<p>To run the simulations, follow these steps:
</p>
<ol>
  <li>compile the mod files using nrnivmodl under Mac OS X and Linux, or
mknrndll under Windows
  </li><li>run mosinit.hoc in NEURON. Clicking Init &amp; Run button in RunControl
panel performs the simulation of propagating action potentials along
mossy fiber axons and plots the results using NEURON's graphical user
interface.
  </li><li>click radio buttons in the panel "passive_propagation" and click
"Init &amp; Run" in the RunControl panel to perform simulation shown in
Figs. 4G and 4H.
</li></ol>
<p>
  Here are screenshots of pressing the successive buttons available in the GUI that is presented when you start the simulation:</p>
<p/><img src="images/screenshot1.png" alt="screenshot 1">
<p/><img src="images/screenshot2.png" alt="screenshot 2">
<p/><img src="images/screenshot3.png" alt="screenshot 3">
<p/><img src="images/screenshot4.png" alt="screenshot 4">
					
<p>Questions about this model should be directed to <a href="mailto:kamiya@med.hokudai.ac.jp">kamiya@med.hokudai.ac.jp</a>.</p>
</html>