GitHub - ModelDBRepository/267047: Two-neuron conductance-based model with dynamic ion concentrations to study NaV1.1 channel mutations

ModelDBRepository / 267047 Public

Notifications You must be signed in to change notification settings
Fork 1
Star 0

Two-neuron conductance-based model with dynamic ion concentrations to study NaV1.1 channel mutations

modeldb.science/267047

Notifications

Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
ic		ic
par		par
screenshots		screenshots
2_neurons.ode		2_neurons.ode
readme.html		readme.html

Repository files navigation

<html>

<head>
<style>
h1 {
   font-size: 1.2em;
}
h2 {
   font-size: 1em;
}
</style>
</head>

<body>

<h1>Usage</h1>
We give here <a href="http://www.math.pitt.edu/~bard/xpp/xpp.html" target="_blank">XPP</a> files corresponding to the simulations shown in Fig 4 and Fig 12 of <a href="https://hal.inria.fr/hal-03191275" target="_blank">https://hal.inria.fr/hal-03191275</a>. Initial condition and parameter value files for the different conditions are given in the folders "ic" and "par". From the folder containing "2_neurons.ode", type the commands below in a terminal and then click on "Initialconds", "Go". 

<h2>Control condition</h2>
xppaut 2_neurons.ode -parfile par/control.par -icfile ic/control.ic<br/><br/>
<img src="screenshots/control_condition.png" alt="screenshot" width="500"><br/><br/>

<h2>FHM-3 mutation of NaV1.1</h2>
xppaut 2_neurons.ode -parfile par/migraine.par -icfile ic/migraine.ic<br/><br/>
<img src="screenshots/fhm_mutation.png" alt="screenshot" width="500"><br/><br/>

<h2>Epilptogenic mutation of NaV1.1</h2>
xppaut 2_neurons.ode -parfile par/epilepsy.par -icfile ic/epilepsy.ic<br/><br/>
<img src="screenshots/epileptogenic_mutation.png" alt="screenshot" width="500">

</body>

</html>