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README_file

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morphology

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README.htm

README.htm

 
 

cacumm.mod

cacumm.mod

 
 

cagk.mod

cagk.mod

 
 

cal2.mod

cal2.mod

 
 

can2.mod

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cat.mod

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cell_seed2_0.hoc

cell_seed2_0.hoc

 
 

h.mod

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h_pas.mod

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kadist.mod

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kaprox.mod

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kca.mod

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kdb.mod

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kdbm.mod

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kdrbca1.mod

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kmb.mod

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mosinit.hoc

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na3n.mod

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<div class=WordSection1>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>Model files
in the NEURON simulation environment (v8.0.0) from the paper:<o:p></o:p></span></p>

<p class=MsoNormal><span class=SpellE><span style='mso-bidi-font-family:Calibri;
mso-bidi-theme-font:minor-latin;color:#212121;background:white'>Spoleti</span></span><span
style='mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;color:#212121;
background:white'>, E., <span class=SpellE>Krashia</span>, P., La Barbera, L.,
Nobili, A., <span class=SpellE>Lupascu</span>, C. A., Giacalone, E., Keller,
F., Migliore, M., Renzi, M., &amp; D'Amelio, M. (2021). </span><b
style='mso-bidi-font-weight:normal'><span lang=EN-US style='mso-bidi-font-family:
Calibri;mso-bidi-theme-font:minor-latin;color:#212121;background:white;
mso-ansi-language:EN-US'>Early derailment of firing properties in CA1 pyramidal
cells of the ventral hippocampus in an Alzheimer's disease mouse model</span></b><span
lang=EN-US style='mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;
color:#212121;background:white;mso-ansi-language:EN-US'>.&nbsp;</span><i
style='box-sizing: inherit;font-variant-ligatures: normal;font-variant-caps: normal;
orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;
text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;
word-spacing:0px'>Experimental neurology</i><span style='font-variant-ligatures: normal;
font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;
text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;
float:none;word-spacing:0px'>,&nbsp;</span><i style='box-sizing: inherit;
font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:
start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;
text-decoration-style: initial;text-decoration-color: initial;word-spacing:
0px'>350</i><span style='font-variant-ligatures: normal;font-variant-caps: normal;
orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;
text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;
float:none;word-spacing:0px'>, 113969. Advance online publication.
https://doi.org/10.1016/j.expneurol.2021.113969</span></span><span lang=EN-US
style='mso-bidi-font-family:Calibri;mso-bidi-theme-font:minor-latin;mso-ansi-language:
EN-US'><o:p></o:p></span></p>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>Auto-launch
from <span class=SpellE>ModelDB</span> or:<o:p></o:p></span></p>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>Compile the
mod files with <span class=SpellE>mknrndll</span> (<span class=SpellE>mswin</span>
or graphical mac) or <span class=SpellE>nrnivmodl</span> (<span class=SpellE>unix</span>/<span
class=SpellE>linux</span>)). Start the simulation by (<span class=SpellE>unix</span>/<span
class=SpellE>linux</span>) typing on the command line:<o:p></o:p></span></p>

<p class=MsoNormal><span class=SpellE><span lang=EN-US style='mso-ansi-language:
EN-US'>nrngui</span></span><span lang=EN-US style='mso-ansi-language:EN-US'> <span
class=SpellE>mosinit.hoc</span><o:p></o:p></span></p>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'>or (mac <span
class=SpellE>os</span> x) drag and dropping the <span class=SpellE>mosinit.hoc</span>
file on the <span class=SpellE>nrngui</span> icon or (<span class=SpellE>mswin</span>)
double clicking on the <span class=SpellE>mosinit.hoc</span> file.<o:p></o:p></span></p>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'><o:p>&nbsp;</o:p></span></p>

<p class=MsoNormal><span class=SpellE><span lang=EN-US style='mso-ansi-language:
EN-US'>mosinit.hoc</span></span><span lang=EN-US style='mso-ansi-language:EN-US'>
will reproduce the simulated traces in Fig.5 of the paper:<o:p></o:p></span></p>

<p class=MsoListParagraphCxSpFirst style='text-indent:-18.0pt;mso-list:l0 level1 lfo2'><![if !supportLists]><span
lang=EN-US style='mso-ascii-font-family:Calibri;mso-fareast-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-ansi-language:
EN-US'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span></span></span><![endif]><span class=SpellE><span lang=EN-US
style='mso-ansi-language:EN-US'>The&quot;WT</span></span><span lang=EN-US
style='mso-ansi-language:EN-US'> 3m 0.25nA&quot; and 'WT 3m 0.5nA&quot; buttons
reproduce the 3-months WT cell's trace at 0.25nA and 0.5nA respectively, in
fig.5A.<o:p></o:p></span></p>

<p class=MsoListParagraphCxSpMiddle style='text-indent:-18.0pt;mso-list:l0 level1 lfo2'><![if !supportLists]><span
lang=EN-US style='mso-ascii-font-family:Calibri;mso-fareast-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-ansi-language:
EN-US'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span></span></span><![endif]><span lang=EN-US style='mso-ansi-language:EN-US'>The
&quot;TG 3m 0.25nA&quot; and 'TG 3m 0.5nA&quot; buttons reproduce the 3-months
TG cell's trace at 0.25nA and 0.5nA respectively, in fig.5A.<o:p></o:p></span></p>

<p class=MsoListParagraphCxSpMiddle style='text-indent:-18.0pt;mso-list:l0 level1 lfo2'><![if !supportLists]><span
lang=EN-US style='mso-ascii-font-family:Calibri;mso-fareast-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-ansi-language:
EN-US'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span></span></span><![endif]><span lang=EN-US style='mso-ansi-language:EN-US'>The
&quot;WT 8m 0.2nA&quot; and 'WT 8m 0.25nA&quot; buttons reproduce the 8-months
WT cell's trace at 0.2nA and 0.25nA respectively, in fig.5B.<o:p></o:p></span></p>

<p class=MsoListParagraphCxSpLast style='text-indent:-18.0pt;mso-list:l0 level1 lfo2'><![if !supportLists]><span
lang=EN-US style='mso-ascii-font-family:Calibri;mso-fareast-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-ansi-language:
EN-US'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</span></span></span><![endif]><span lang=EN-US style='mso-ansi-language:EN-US'>The
&quot;TG 8m 0.2nA&quot; and 'TG 8m 0.25nA&quot; buttons reproduce the 8-months
TG cell's trace at 0.2nA and 0.25nA respectively, in fig.5B.<o:p></o:p></span></p>

<p><span lang=EN-US style='font-size:11.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:
minor-latin;color:black;mso-ansi-language:EN-US'>Questions on how to use this
model&nbsp;</span><span class=grame><span style='font-variant-ligatures: normal;
font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;
text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;
word-spacing:0px'><span lang=EN-US style='mso-ansi-language:EN-US'>should be
directed</span></span></span><span style='font-variant-ligatures: normal;
font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;
text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;
float:none;word-spacing:0px'><span lang=EN-US style='mso-ansi-language:EN-US'>&nbsp;to&nbsp;</span></span><span
lang=EN-US style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin;
mso-ansi-language:EN-US'><a href="mailto:elisabetta.giacalone@ibf.cnr.it"
style='font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;
text-align:start;widows: 2;-webkit-text-stroke-width: 0px;word-spacing:0px'>elisabetta.giacalone@ibf.cnr.it</a>
or <a href="mailto:carmen.lupascu@ibf.cnr.it">carmen.lupascu@ibf.cnr.it</a><o:p></o:p></span></p>

<p><span lang=EN-US style='font-size:11.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:
minor-latin;color:black;mso-ansi-language:EN-US'>If you need more help running
the model on your platform, please consult this page:<o:p></o:p></span></p>

<p><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin;
color:black'><a
href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml"
target="_blank"></p\><span lang=EN-US style='mso-ansi-language:EN-US'>https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</span></a></span><span
lang=EN-US style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin;
color:black;mso-ansi-language:EN-US'><o:p></o:p></span></p>

<p class=MsoNormal><span lang=EN-US style='mso-ansi-language:EN-US'><o:p>&nbsp;</o:p></span></p>

</div>

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A model of ventral Hippocampal CA1 pyramidal neurons of Tg2576 AD mice (Spoleti et al. 2021)

modeldb.science/267066

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