The NEURON simulations described here describe the effect of the neuronal glutamate transporte EAAC1 in regulating synaptic integration and the firing output of D1-MSNs.
This is addressed using either a simplified ball-and-stick morphology (see Ball and Stick folder) or a realistic morphology for D1-MSNs in the dorsolateral striatum of EAAC1+/+ and EAAC1-/- mice, obtained from biocytin filles (see Realistic Morphology folder).
Each folder contains NEURON codes used to establish the synaptic weight of AMPA, NMDA and GABA inputs.
The mod files, included in a separate folder (mod_files), are adapted, in part, from Mattioni and LeNovère (2013).
These models were created by Maurice Petroccione, graduate student in Annalisa Scimemi's lab at SUNY Albany.
For additional information, please contact:
Maurice Petroccione (developer)
Annalisa Scimemi (supervisor)
Department of Biology
1400 Washington Avenue (BIO329)
Albany, NY 12222-0100 (USA)