Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France
Formerly from (when this work was created):
Department of Physiology, Laval University,
Quebec G1K 7P4, Canada
Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html
This package is running with the NEURON simulation program written by Michael Hines and available on internet at:
The package contains mechanisms (.mod
files) and programs (.oc
files) needed
to simulate different models of thalamocortical (TC) relay neurons, relative
to the paper:
Destexhe A, Neubig M, Ulrich D and Huguenard JR. Dendritic low-threshold calcium currents in thalamic relay cells. Journal of Neuroscience 18: 3574-3588, 1998. https://pubmed.ncbi.nlm.nih.gov/9570789/
tc1_cc.oc
- current clamp in 1-compartment TC celltc3_cc.oc
- current clamp in 3-compartment TC celltc200_cc.oc
- current clamp in 200-compartment TC cell (intact cell)tc200_vc.oc
- voltage clamp in 200-compartment TC cell (intact cell)tcD_cc.oc
- current clamp in 8-compartment TC cell (dissociated cell)tcD_vc.oc
- voltage clamp in 8-compartment TC cell (dissociated cell)
hh2.mod
- fast sodium spikes (Na and K currents)ITGHK.mod
- T-type calcium current of TC cellscadecay.mod
- intracellular calcium dynamicsVClamp.mod
- mechanism for single-electrode voltage-clamp
Use autolaunch on modeldb or:
To compile the demo, NEURON and INTERVIEWS must be installed and working on
the machine you are using. Just type nrnivmodl
to compile the mechanisms
given in the mod files.
Then, execute the main demo program by typing:
nrngui mosinit.hoc
Compile the mechanism (mod) files by using mknrndll
. Then start the simulation
by clicking on mosinit.hoc
in windows explorer.
Once the menu and graphics interface has appeared, click on a simulation from the Simulations of TC cells window. Then click on "Init and Run" button to start the simulation on the RunControl window. If you do not see a RunControl window you can bring it to the front by selecting it under Tools from the NEURON main menu.
For more information about how to get NEURON and how to install it, please refer to the following sites:
For further information, please contact:
Alain Destexhe
Laboratory for Computational Neuroscience
Unité de Neurosciences Intégratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France
Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html
- Further updated 7/10/05 for button restart fix.
- model version 10/28/02 updated to neuron 5.2.
- readme standardized to markdown, NEURON and PubMed links updated 12/01/23.