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Oscillating neurons in the cochlear nucleus (Bahmer Langner 2006a, b, and 2007)
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This is the readme for the models associated with the papers: Bahmer A, Langner G (2006) Oscillating neurons in the cochlear nucleus: I. Experimental basis of a simulation paradigm. Biol Cybern 95:371-9 Bahmer A, Langner G (2006) Oscillating neurons in the cochlear nucleus: II. Simulation results. Biol Cybern 95:381-92 Bahmer A, Langner G (2007) Simulation of oscillating neurons in the cochlear nucleus: a possible role for neural nets, onset cells, and synaptic delays. Andreas Bahmer and Gerald Langner, in "Hearing - from basis research to applications", Eds.: B KOllmeier, G Klump, V Hohmann, U Langemann, M Mauermann, S Uppenkamp, J Verhey; Springer, Heidelberg, in press. The NEURON files are the basis for the figure 2b in Bahmer A, Langner G (2007) The matlab files for the Chopper neurons (Topology I and II correspond to Bahmer and Langner 2006 I II Usage: NEURON_Chopper_Network_Simulation: Either Auto-launch from ModelDB or -------------------- 1) download and extract the archive. 2) compile the mod files unix/linux: use the nrnivmod command in the NEURON_Chopper_Network_Simulation folder mswin: use mknrndll to compile the mode files in the NEURON_Chopper_Network_Simulation folder mac OS X: drag and drop the NEURON_Chopper_Network_Simulation folder on the mknrndll icon 3) run the simulation by unix/linux: type nrngui mosinit.hoc in the NEURON_Chopper_Network_Simulation folder. mswin: double click on mosinit.hoc in the NEURON_Chopper_Network_Simulation folder mac OS X: drag and drop the NEURON_Chopper_Network_Simulation folder on the nrngui icon. -------------------- Now that the simulation is running you can recreate the figure 2b in the paper by clicking on the "Run" button above the "save matrix" button". The simulation runs 20 times. Then press the "save matrix" button. This saves the traces in rothman.txt for later analysis and graphing in matlab with the import_matlab.m script. Please erase the first line in "rothman.txt" by hand for the import_matlab.m script. General description of script contents: circuitroth120pA.ses: Network of two chopper neurons. loop.hoc: Loops the network with increasing input strength. The file has to be loaded within the circuitroth120pA Session from the GUI. A matrix can be saved in a file "rothman.txt". This file can be read in matlab with "import_matlab.m" (after it's first line is erased) More matlab notes: In addition in the "include" folder there are function files which are the neurons and synapses and some other files that are needed for the simulation. The interface for the nerve and the onset simulation is open: "anft" is the variable for the nerve input (example: 000205010020033... sampling 25us). As it is presumed that the chopper have an input of a frequency channel with 5 synapses it is subdivided. (anft==5 anft==4...) "onsett" is the variable for the onset neuron input. (only zeros and ones, example: 001000010000) Onset neuron is from Rothman and Manis (which is also stored in ModelDB). Good test choices are anft as long as onsett, anft can contain numbers up to 5, onsett only 1 and 0, like: anft= [1 1 0 0 3 5 4 1 0 0 5 4 3 0] onsett=[0 0 0 0 0 1 1 0 0 0 1 1 0 0] The LIF neurons have a stochastic component. In my simulations, I have simulated the nerve and onset neuron with many repetitions (the nerve contains stochastic elements) and stored it. The data was a matrix, in which each colomns are time slits and rows are one repetition with 25 us precision. The next step was that matlab reads one line of nerv ( number for amount of APs and zeros) and onset (just zeros and ones, ones for an AP) and then simulates the choppers and stores the chopper result. This step was repeated as often as the number of repetions. Dr. Andreas Bahmer Dr.rer.nat. Dipl.-Phys. cand. med. Klinkum der Johann Wolfgang Goethe Universität Klinik für Hals-Nasen-Ohrenheilkunde Audiologische Akustik, Prof. Dr.- Ing. Uwe Baumann Theodor-Stern-Kai 7, 60590 Frankfurt am Main Update 2008-07-04: For a graphical user interface: with the compiler toolbox from matlab we made a standalone exe-file provided in the distrib subfolder in the ModelDB (expanded) archive but you have to install a "MCR-installer" (free) which I also provide on my homepage (sorry it is in german) http://home.arcor.de/a.bahmer/software.html Installationsprogramm für neue compilierte Matlabprogramme ab R2007a (EXE-File)
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Oscillating neurons in the cochlear nucleus (Bahmer Langner 2006a, b, and 2007)
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