Vocab. HEMONC

HemOnc

HemOnc.org is a community-driven knowledge and reference base of medical oncology and hematology available as wiki website. An extract of the HemOnc wiki is implemented as standardized Vocabulary for the purpose of having a standard set of concepts to represent chemotherapy regimens as well as their components and qualities.

HemOnc vocabulary features a complex non-linear OWL ontology which is preserved in standardized tables.

Sources

• HemOnc repository

Domain

Concepts in HemOnc vocabulary belong to one of three Domains below:

Domain	Notes
Regimen	concepts represent treatment protocols as combination of antineoplastic and supporting drugs or other therapies administered in certain order.
Procedure	concepts represent medical and surgical procedures and therapies as well as their context like line of therapy or intent.
Drug	concepts represent singular components of antineoplastic regimens and their attributes.
Condition	concepts represent Neoplastic, Immune or Hematological conditions relevant to therapies listed in three sibling domain within the vocabulary.

Concept Classes by Domain

Domain	Concept Class	Meaning
Regimen	Modality	Type and modality of regimens
:::	Regimen	Chemo-, immuno- and radiotherapy regimens. Standard concepts belonging to this domain are intended to be put in episode_concept_id field of Episode table
Procedure	Context	Procedures and therapy contexts like line of therapy or intent
:::	Procedure	Medical and surgical procedures
Drug	Brand Name	Marketed name of a drug component
:::	Component	Generic molecule name of drug component
:::	Component Class	Pharmaceutical group to which drug components belong
:::	Route	Route of drug administration
:::	Regimen Class	Clinical-pharmacological classificators commonly used in real pratice
Condition	Condition	Conepts for hemotological (including immune-mediated) and oncological conditions

Standard status and mapping

All valid Regimen domain concepts and Procedure Context concepts are Standard and map to self. Component Class concepts serve as Classification concepts.

The remaining concept in HemOnc Vocabulary are non-standard and have mappings to standard concepts when available.

Hierarchy

HemOnc vocabulary has hierarchical relations both internal and to external vocabularies.

Component Class subsumes standard Drug concepts from RxNorm and RxNorm Extension concepts.

Procedure Context, and Regimens and Component Class concepts are also organized in ontological hierarchy.

Non-standard concepts have hierarchical relationships, but they do not participate in forming CONCEPT_ANCESTOR table.

Relationship

HemOnc vocabulary includes complex set of hierarchical and attributive relationships. Such relations show which drug components belong to regimen, which modality regimens belong to or what is the context of the performed procedure.

Important relations from regimens to components:

Relationship
Has AB-drug cjgt
Has AB-drug cjgt Rx
Has antineoplastic
Has antineopl Rx
Has cytotoxic chemo
Has cytotox chemo Rx
Has endocrine tx
Has endocrine tx Rx
Has immunosuppressor
Has immunosuppr Rx
Has immunotherapy
Has immunotherapy Rx
Has local therapy
Has local therap Rx
Has pept-drug cjgt
Has pept-drg cjg Rx
Has radioconjugate
Has radiocjgt Rx
Has radiotherapy
Has radiotherapy Rx
Has steroid tx
Has steroid tx Rx
Has supportive med
Has support med Rx
Has targeted therapy
Has targeted tx Rx

Please consult CONCEPT_RELATIONSHIP table for full list of relations.

References

• HemOnc.org website
• Implementation poster
• HemOnc: A new standard vocabulary for chemotherapy regimen representation in the OMOP common data model
• Extending the OMOP Common Data Model and Standardized Vocabularies to Support Observational Cancer Research