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prediction interval and error analysis #400

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KaixiangZhou opened this issue Oct 18, 2019 · 4 comments
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@KaixiangZhou
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@KaixiangZhou KaixiangZhou commented Oct 18, 2019

Hi, I built the PBPK model and input the observed data, but how to analysis the predictive accuracy?  For example, how to obtain the following figures? Thank you very much.

Dr. Zhou

GEWFU7F97%U7NRM %`R0K)M

P{WGFA_D%(TV$)6` (T8GD6

@regulus92

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@regulus92 regulus92 commented Oct 18, 2019

You can use R or other statistical softwares with plotting function.

@KaixiangZhou

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@KaixiangZhou KaixiangZhou commented Oct 18, 2019

@Yuri05

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@Yuri05 Yuri05 commented Oct 18, 2019

@KaixiangZhou you might also take a look at the new qualification framework provided as an AddOn to the OSP Suite (s. here for details and download instructions). This framework allows creation of qualification reports (also across projects) with variety of plots (e.g. predicted vs. observed).

You need to write a so called "qualification plan" (s. here for details) where you can define what kind of plots, tables and qualification measures you would like to see in your report.
This plan is processed then by the qualification tools to generate a report.

Qualification Plan (click to expand)

Here you can see some examples of qualification plans and corresponding reports:

Best starting point is: take the template from https://github.com/Open-Systems-Pharmacology/Evaluation-plan-template and adjust it to your needs

@Incei @sfrechen @TWendl FYI

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@prvmalik prvmalik commented Oct 18, 2019

There is a manual way to export the observed and simulated AUC, CL, Vd etc. from your simulations so that you can make the plots above.

Individual Simulations: Click 'Show PK Analysis' and Click 'Export to Excel'
IndividSim

Population Simulations: Click 'Export' in the top toolbar when your population simulation is open, then click 'PK-analyses-to-CSV'
PopSim

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