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Whole-body PBPK model of gemfibrozil as CYP2C8 and OATP1B1 DDI perpetrator drug

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Gemfibrozil-Model

Whole-body PBPK model of gemfibrozil as CYP2C8 and OATP1B1 DDI perpetrator drug

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Within this repository, we distribute a whole-body parent-metabolite PBPK model of gemfibrozil and gemfibrozil 1-O-β-glucuronide, that has been carefully developed using a large number of clinical studies and evaluated within our DDI modeling network.

The PK-Sim project file contains simulations of all published clinical studies employed during model establishment, including the respective observed data digitized from literature reports. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [1].

Version information

PK-Sim Version 7.4.0

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clinical Pharmacokinetics 2019, https://link.springer.com/article/10.1007/s40262-019-00777-x

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Whole-body PBPK model of gemfibrozil as CYP2C8 and OATP1B1 DDI perpetrator drug

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