Whole-body PBPK model of gemfibrozil as CYP2C8 and OATP1B1 DDI perpetrator drug
Within this repository, we distribute a whole-body parent-metabolite PBPK model of gemfibrozil and gemfibrozil 1-O-β-glucuronide, that has been carefully developed using a large number of clinical studies and evaluated within our DDI modeling network.
The PK-Sim project file contains simulations of all published clinical studies employed during model establishment, including the respective observed data digitized from literature reports. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [1].
PK-Sim Version 7.4.0
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The model code is distributed under the GPLv2 License.
[1] Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clinical Pharmacokinetics 2019, https://link.springer.com/article/10.1007/s40262-019-00777-x