Application of early warning signs to physiological contexts: A comparison of multivariate indices in patients on long-term hemodialysis

Véronique Legault, Yi Pu, Els Weinans, and Alan A. Cohen

Codes for indices calculation

1. Functions for indices calculation
2. Indices calculation: used for all figures except Suppl Fig. 4
3. Indices calculation_diff time windows: used for Supplementary Figs 3-6
4. MMD calculation_no avg: used for Fig. 4

Codes for main figures

1. Figure 1: Distributions of indices
2. Figure 2: Correlations among indices
3. Figure 3: Trends before death for each index
4. Figure 4: Mortality prediction

Codes for supplementary figures

1. Supp figure 1: Effect of variable transformation on indices calculation
2. Supp figure 2: Effect of variable transformation on NMV calculation
3. Supp figures 3 and 4: Correlations among indices calculated using different time windows
4. Supp figure 5: Effect of time window used for indices calculation on trends before death
5. Supp figure 6: Effect of time window used for indices calculation on mortality prediction
6. Supp figure 7: Effect of indices combination on the AUC