Implementation of the 2-parameter logistics randomised mode for a candidate in the AGILE platform described in
How to Make An Adaptive Design Work in Practice: Implementation of Bayesian Adaptive Phase I Design for COVID-19 Treatments by a Clinical Trial Unit During a Pandemic
The repository includes the following files:
- BLRM-Randomised-AGILE-SIMULATIONS.R
This code uploads the required functions and implements the 2-parameter logistic (also known as BLRM) randomised design in the case of a single-agent trial with binary (DLT/no DLT) outcomes.
This code can be used to produce the performance of the proposed design provided in Table 3.