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@mtcicero26 mtcicero26 released this 16 Apr 21:31
· 515 commits to main since this release

⚠️ Reverse-strand MM/ML parsing bug — UPGRADE TO v2.9.0

Versions 2.6 – 2.8.2 had a parser bug that shifted m6A/m5C modification positions on reverse-aligned reads (~24 bp median), causing ns/nl/as/al/MA/AQ tags to be wrong on reverse reads. Forward reads unaffected. DAF with IUPAC (R/Y) encoding unaffected.

Upgrade: pip install --upgrade fiberhmm (v2.9.0+). See v2.9.0 release notes for details.


⚠️ DO NOT USE — CRITICAL DATA-INTEGRITY BUG (streaming pipeline)

Silent chunk-eating bug: streaming pipeline drops reads and produces 0 reads with tags when input has more than one chunk worth of reads.

Fix: upgrade to v2.6.9 or later (v2.7.0+ recommended).

pip install --upgrade fiberhmm