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FiberHMM 3.0.2

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@mtcicero26 mtcicero26 released this 16 Oct 21:58

Fixed

  • fiberhmm-qc grades DddA against a somatic DddA control. The packaged
    DddA reference was built from a sperm DAF-seq sample (0.7% median
    deamination, no nucleosome phasing), so normal DddA libraries failed the
    signal rate and the periodicity grade compared them with a flat curve. The
    rate, phasogram, footprint-size and example-molecule references now come
    from the NAPA and UBA1 DddA amplicons (14.6% median deamination, NRL 202
    bp). DddA periodicity allows 15 bp around the reference NRL, since amplicon
    loci differ in repeat length. Re-run fiberhmm-qc on DddA BAMs; calls are
    unchanged, and DddB and Hia5 grades are unchanged.
  • The nucleosome-size legend no longer covers the long-span note in QC plots.