NTR: [Hair bundle reversal]

[MariaLivia]

Please provide as much information as you can:

• Suggested term label:

• Reversal of hair-bundle orientation

• Definition (free text)
  Coordinated organization of stereociliary bundles into two populations that differ by 180 degrees defining a line of polarity reversal (LPR) across which hair cells are arranged in opposite orientations.

• Reference, in format PMID:#######
  PMID:10900087
  PMID:34646115
  PMID:32965215
  PMID:34001891

• Gene product name and ID to be annotated to this term

• Emx2 Q04744

• Gpr156 Q6PCP7

• Parent term(s)

• GO:0001736 ???

• GO:0060121 ???

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

[MariaLivia]

Hi,
any news about this term request? I see there is no assignee.

[pgaudet]

For parents, I dont think GO:0001736 establishment of planar polarity is right; it would make it a child of
GO:0001738 morphogenesis of a polarized epithelium and GO:0002009 morphogenesis of an epithelium.

The other suggestion seems more appropriate: GO:0060121 vestibular receptor cell stereocilium organization (althouh I didn't look closely and I dont know this process). Would this is is_a or part_of the process?

The issue I see that that this term would be the only child of 'GO:0060121 vestibular receptor cell stereocilium organization'.
If this new proposed term should be is_a GO:0060121 vestibular receptor cell stereocilium organization, then are there other possible mechanisms or organization patterns?

If this new proposed term should be part_of GO:0060121 vestibular receptor cell stereocilium organization, then are there other subparts of this process?

Thanks, Pascale

[raymond91125]

vestibular receptor cell stereocilium organization is a form of establishment of planar polarity https://en.wikipedia.org/wiki/Planar_cell_polarity.
Although PMID:34646115 "A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs" suggests that there needs to be a term that covers both type of cells.

[raymond91125]

The fish emx2 is already annotated with GO:0060121 vestibular receptor cell stereocilium organization based on PMID:28266911 regarding LPR. We should have a more general term "stereocilium bundle organization" to cover the shared process in all hair cells. We may decide on having more granular terms (LPR vs non-LPR aspects of organization) later. @MariaLivia Do you think this is good?

[raymond91125]

+[Term]
+id: GO:0160194
+name: stereocilium bundle organization
+namespace: biological_process
+def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a sensory hair cell stereocilium bundle." [PMID:28266911, PMID:6978627]
+intersection_of: GO:0016043 ! cellular component organization
+intersection_of: results_in_organization_of GO:0032421 ! stereocilium bundle
+property_value: term_tracker_item "#27056" xsd:anyURI
+created_by: rynl
+creation_date: 2024-07-08T20:47:33Z

[raymond91125]

I'm closing this ticket for now. Please feel free to reopen if more action is needed. Thanks!

[MariaLivia]

The new term is fine for me. Thank you !