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Identification of 13 independent genetic loci associated with cognitive resilience in healthy ageing in 330,097 individuals in the UK Biobank .

Code used to create the GWAS-by-subtraction of Resilience , and for follow-up analyses.

  1. Generation of initial GWAS of EY + Res and EY/NonRES and EY and RT for futher analysis (Generation_of_GWAS.sh)
  2. Code for GWAS-by-Subtration (GWAS-by-subtraction.sh)
  3. Calculation of sample size after GWAS-by-Subtration (GBS_sample_size.sh)
  4. Conditional analysis(Conditional_analysis.sh)
  5. FINEMAP (FINEMAP.sh)
  6. Drawing Venn diagram (Venn_diagram.sh)
  7. Magma analysis(MAGMA.sh)
  8. LD score regression analysis (LDSC.sh)
  9. Generalised Summary statistics-based Mendelian Randomisation (GSMR.sh)
  10. Removal of locus on chromosome 3 (GBS_minus_locus3.sh)
  11. GWAS of Resilience

During the couse of this analysis the terms used for the inputs and outputs to GWAS-by-Subtraction changed as follows: for RV read EY+Res and for V read EY/NonRes for res read Resilience and for var read EduYears analysis

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