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XDN: JN.1.1/JD.1 recombinant (20 seqs, 2 countries) #1158

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aviczhl2 opened this issue Dec 7, 2023 · 11 comments
Closed

XDN: JN.1.1/JD.1 recombinant (20 seqs, 2 countries) #1158

aviczhl2 opened this issue Dec 7, 2023 · 11 comments

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@aviczhl2
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aviczhl2 commented Dec 7, 2023

This is the 5th non-singlet recomb of BA.2.86*. I thought it was a singlet but @FedeGueli found there's already one being removed by usher.

image

JN.1.1--JD.1
Breakpoint between 24379 and 24989

Additional mutations: C280T, C11812A,

C280T from a JN.1.1 branch
C11812A is private mutations

GISAID query: C11812A, T28282C, C280T
No. of seqs : 2(UK)
EPI_ISL_18552726, 2023
EPI_ISL_18592162, 2023-11-26

usher
image

@aviczhl2
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+1 Wales

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (2 seqs, UK) JN.1.1/JD.1 recombinant (3 seqs, UK) Dec 18, 2023
@aviczhl2
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It seems that seqs of this branch weren't added to usher despite I put it on recombinants.tsv @AngieHinrichs.

@AngieHinrichs
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Thanks for the heads-up. It is a little more complicated for COG-UK sequences because they tend to be present in all three of GISAID, COG-UK and INSDC, and I need to make sure that the INSDC accession is not excluded. I will work on it and hopefully they'll be added tomorrow (2023-12-20).

@aviczhl2
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aviczhl2 commented Dec 26, 2023

+1 Wales.

Oh I find them actually on usher.

image

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (3 seqs, UK) JN.1.1/JD.1 recombinant (4 seqs, UK) Dec 26, 2023
@aviczhl2
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+3 Wales

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (4 seqs, UK) JN.1.1/JD.1 recombinant (7 seqs, UK) Dec 26, 2023
@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (7 seqs, UK) JN.1.1/JD.1 recombinant (8 seqs, UK) Dec 27, 2023
@aviczhl2
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+1 England

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (8 seqs, UK) JN.1.1/JD.1 recombinant (9 seqs, UK) Jan 2, 2024
@aviczhl2
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aviczhl2 commented Jan 7, 2024

There's one more seq without 14425T. Change query.

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (9 seqs, UK) JN.1.1/JD.1 recombinant (10 seqs, UK) Jan 7, 2024
@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (10 seqs, UK) JN.1.1/JD.1 recombinant (16 seqs, UK) Jan 9, 2024
@JosetteSchoenma
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Since we discussed this one in the private group after I spotted it at the 1st of December, I got some extra info.

The date for EPI_ISL_18552726 is 2023-11-21 (not on GISAID).

Alternative query from @FedeGueli
C11747T, C11812A, C14425T

6 extra ones showed up yesterday. Will compare results later.

Screenshot_20240109_082801_X.jpg

I got another breakpoint, so I will have a better look at that too.

It gained Orf8:8G* !

@aviczhl2
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+4 USA

@aviczhl2 aviczhl2 changed the title JN.1.1/JD.1 recombinant (16 seqs, UK) JN.1.1/JD.1 recombinant (20 seqs, 2 countries) Jan 11, 2024
@FedeGueli FedeGueli added To be proposed Green light for proposal and removed Rapid review needed labels Jan 11, 2024
@FedeGueli
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Please propose it.

@FedeGueli FedeGueli changed the title JN.1.1/JD.1 recombinant (20 seqs, 2 countries) XDN: JN.1.1/JD.1 recombinant (20 seqs, 2 countries) Jan 16, 2024
@FedeGueli FedeGueli added JN.1 Spike XDN and removed To be proposed Green light for proposal labels Jan 16, 2024
@FedeGueli
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Designated XDN via cov-lineages/pango-designation@cd3327a

@aviczhl2 aviczhl2 added this to the XDN milestone Jan 17, 2024
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