Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the adult, characterized by degeneration of motor neurons in the spinal cord, brain stem and motor cortex. There is no bio-informatic model of ALS.
A set of ImageJ plugins to quantify dynamics, morphology, and fluorescence of microglial cells.
ImageJ macro for morphological analysis
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease.
IGFBPL1 Retinal Microglia Project | Dong Feng Chen Lab collaboration | Schepens Eye Research Institute, Mass General Hospital, Harvard Medical School
Scripts to segment microglia images and generate reports
ImageJ macros to analyse microglial cells in live or fixed tissue (Work-in-progress)
In Alzheimer’s disease, abnormal levels of the Aβ protein aggregate together to form Aβ plaques. The response to plaques by microglial cells is characterised by changes in gene expression and an increase in cell density surrounding plaques. This set of semi-automated macros calculates both microglial density and changes in protein expression int…
Triple single cell analysis of microglia cell types for studying PIEZO1 alterations in Alzheimer patients
Mathematical modelling of microglial cells for the neuroscience community
Socs3/Spp1 Project on Microglia in OIR | Ye Sun Lab Collaboration Project | Boston Children's Hospital
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