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phagepickr is a bioinformatics tool designed to create evolution-proof bacteriophage cocktails. By analyzing bacterial receptor profiles, it selects phage combinations that maximize host compatibility and minimize bacterial resistance.
Key Features
- Targeted Design: Generates phage cocktails tailored for specific bacterial species (e.g., E. coli, K. pneumoniae).
- Phage Discovery: Uses a nearest-neighbor algorithm to identify phage candidates from phenotypically similar bacteria.
- Maximized Diversity: Identifies the most distant phages via alignment to target multiple receptors.
- Automated Data Retrieval: Automatically fetches metadata via NCBI Entrez.
- Built-in Datasets: Includes pre-processed bacterial receptor and phage-host data.
Installation
git clone https://github.com/Alebraco/phagepickr
cd phagepickr
conda env create
conda activate phagepickr