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What exactly is AssemblyScript?
It's both possible to write close-to-the-metal WebAssembly as well as portable code that compiles to WebAssembly using
tsc. As the syntax is just TypeScript, existing tooling can be used in development as well (e.g. for syntax highlighting and refactoring) and common code can easily be shared between the two compilers.
Integrating with Binaryen provides rich validation, optimization (for size and/or speed) and output (WebAssembly text and binary format, asm.js, source maps) capabilities on top of that.