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SYNAPTIK v0.9.0: 3D RNA Biophysics (Turner 2004 Zuker MFE + steric competition), Patient Natural History Digital Twin (1,000-twin PRO-ACT/Answer ALS empirical Bayes Monte Carlo), Clinical Allometry Safety Guardrails & Protocol Corrections, Sugimoto 1995 Nearest-Neighbor Thermodynamic Verification, Literature-Anchored Off-Target Screening, and Concurrent Rate-Limited Literature Ingest. Author: Francesco Nobile (ORCID: 0009-0001-9477-3332).