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Action potential-evoked Na+ influx similar in axon and soma (Fleidervish et al. 2010) (Python)
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<p>
This is an alternative implementation of:<br/>
<div style="margin-left: 2em">
Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging
reveals little difference in action potential-evoked Na+ influx
between axon and soma. Nat Neurosci 13:852-60.
doi:<a href="http://doi.org/10.1038/nn.2574">10.1038/nn.2574</a>.
</div>
</p>
<p>
The author's version is available at
<a href="http://modeldb.yale.edu/136715">http://modeldb.yale.edu/136715</a>.
</p>
<p>
The main differences are:
<ul>
<li>The original was implemented mostly using NEURON's gui tools with a little HOC; this version is implemented in a Python script for NEURON.</li>
<li>The original uses a MOD file to handle sodium accumulation and diffusion; this version use NEURON's reaction-diffusion support.</li>
<li>The original has two additional simulations using a reduced model with no dendrites.</li>
</ul>
</p>
<p>
Two of the three mod files used (<tt>kv</tt>, <tt>Kv1</tt>) have been retained unmodified from the author's version.
The third, <tt>nacurrent</tt> is a simplified version of the original author's <tt>hh_Cs_scaled</tt> after removing the
potassium and leak currents from that file which are not used in this model. The name has been changed to deemphasize the file's historical connection to <tt>hh.mod</tt> as the temperature dependence and rate functions are not intended to be appropriate for modeling a squid.
</p>
<p>
To run, compile the mod files in this directory (on Linux or Mac by changing to this directory and typing <tt>nrnivmodl</tt>; on Windows by dragging this folder to the <tt>mknrndll</tt> icon), then run <tt>mosinit.py</tt> via either:<br/>
<tt> python -i mosinit.py</tt><br/>
or<br/>
<tt> python3 -i mosinit.py</tt><br/>
depending on your Python setup. Choose either "Fig 3A" or "Fig 6B" from the popup, and click "Init & Run". When the simulations complete you should see the respective images below:
</p>Fig 3A:<p/>
<img src="./screenshot3.png">
<p/>Fig 6B:<p/>
<img src="./screenshot6.png">
<p/>
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