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BVSim, a command-line package written in Python, is designed to randomly simulate realistic and comprehensive variations and create human-like genomic sequences by default, with options to learn from input empirical variations of other species. It enables the integration of simple SVs, including deletions, insertions, inversions, tandem duplications, as well as intrachromosomal translocations, both balanced and unbalanced. In addition, it offers parameters to control rates or numbers of small variations, including small indels and SNPs. Furthermore, it can emulate 18 types of CSVs.