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Choose the Windows, Apple Silicon Mac, Intel Mac or Ubuntu x64 download on Installation. Each includes the scientific runtime and offline help. Windows is unsigned; Mac packages are ad-hoc signed without Apple Developer ID signing or notarization. Release checksums accompany the downloads.
The initial barnase–barstar example opens locally. Choose Molecule for coordinates or New construct project for sequence-only work. Open project restores embedded data; Recent projects shows local previews and Recover autosave opens a recovered copy.
Drag to orbit, wheel to zoom and right-drag to pan. Arrow keys rotate, Shift+arrows pan, +/− zoom and F fits. Cmd+K / Cmd+S on Mac, or Ctrl+K / Ctrl+S elsewhere, open Commands and save. Text fields retain normal editing shortcuts. Settings provides Midnight, Liquid Glass and Painted Pixels, standard typography, contrast/transparency controls and layout presets.
Core work is offline. Reference retrieval and published-version checking happen only when explicitly selected. Read Construct-and-maturation, Molecular-inspection and Projects-and-scientific-interpretation before interpreting derived results.