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This repository was archived by the owner on May 18, 2026. It is now read-only.

v1.1.0

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@imallona imallona released this 08 Apr 11:38
· 2 commits to master since this release
c8333f8

Added

  • [workflow] Argelaguet gastrulation dataset: download, format conversion, and analysis report (promoter vs enhancer, as in issue #24)
  • [workflow] CRC cell embeddings report with featureset-wise PCA/UMAP
  • [workflow] Ecker dataset: applied same embedding and sparse representation procedure as other datasets
  • [workflow] adjS vs intervals of DNA methylation
  • [workflow] Coordinate validator (validate.smk, validate_yamet_coords.sh) to check yamet output coordinates
  • [workflow] Simulations restructured into the main snakemake ruleset, reusing Argelaguet's download rules
  • [workflow] Shared embedding utilities (embedding_utils.R)
  • [test] Test case for shannon norm with no infinite values (division by zero edge case)

Fixed

  • [method] Infinite shannon entropy normalisation values caused by division by zero
  • [method] cmake cache and install targets
  • [workflow] Cell embeddings no longer impute missing values; sparse representations handle NAs natively
  • [workflow] HVG/PCA for sparse data where zero and NA carry distinct biological meaning

Changed

  • [workflow] Simulations moved from top-level simulations/ into workflow/rules/simulations.smk and workflow/simulations/
  • [workflow] Cell embeddings standardized across datasets; marginal methylation handled via scaling rather than imputation
  • [automations] Switched to conda-managed envs