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As suggested in http://lists.alioth.debian.org/pipermail/pkg-exppsy-pymvpa/2014q2/002790.html it seems that memmapp'ed access to a .nii file might be slower (I will seek more details about system in a sec). Altogether it might be worthwhile to allow for explicit control either volume should be memmapped or loaded into memory (I guess a kwarg memmap in (None, True, False) to be carried all the way into array_from_file)