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In the latest release off OS-X using the DYLD_LIBRARY_PATH is not possible unless System Integrity Protection (SIP) is disabled.
Meaning that setting the DYLD_LIBRARY_PATH will have no effects on spawned sub shells and therefore using the node client is no longer possible unless one turns off (SIP) as explained here.
This is true in most of the cases, where one starts a subprocess that will run and use the node-oracledb module. This issue meant for discussion on any solutions on how to circumvent disabling SIP or should it just be added as a section to the README and wiki for OS X.