0.1.0 - Preprint version

NucleiSky preprint release

This release marks the first public version of NucleiSky accompanying our preprint:

**NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations **bioRxiv, posted June 29, 2026
DOI: https://doi.org/10.64898/2026.06.29.735028

NucleiSky provides constellation-based point-set registration utilities for microscopy in 2D and 3D, with a focus on aligning partial views, ROIs, and subvolumes to larger reference images or tissue volumes using landmark geometry rather than pixel similarity.

This preprint release includes:

• Core 2D and 3D registration workflows
• Python package installation via PyPI
• Documentation for data preparation, workflows, QC, and troubleshooting

This version is intended as the reference software release for the preprint. Interfaces, defaults, and optional backends may continue to evolve in later versions as we expand testing and user feedback.

If you use NucleiSky in your work, please cite the preprint and report issues or workflow feedback on GitHub.