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Thomas P Spargo edited this page Oct 14, 2022 · 6 revisions

ADPenetrance wiki

Updated 14/10/2022

The repository is maintained by Thomas Spargo (thomas.spargo@kcl.ac.uk) - please reach out with any questions.

Welcome to the ADPenetrance wiki!

This wiki contains usage documentation for each of the R functions associated with this repository.

The adpenetrance function is used for the main penetrance estimation step.

getResidualRisk is a helper function to facilitate quick calculation of the risk of disease among people in sampled familie not inheriting the tested variant. The output of this function is to be passed to the useG argument of adpenetrance.

checkOnsetVariability provides a function for base R plotting of age of onset distributions across two groups. This can be used to give an indication about whether penetrance estimates might be affected substantially by age of sampling when there is a large difference in onset variability between groups of people with and without the variant of interest.

You can navigate to documentation for each function via the sidebar on the right.

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