Occasionally in Safari I get a unstyled admin page, seemingly because the wp-admin/load-styles.php
call failed or timed out.
If static files are simpler for it to serve, it would be beneficial to remove the concatenation, as it serves no purpose other than to reduce network round time trips and most admin pages will have a different set of styles/scripts causing the browser caches to be ignored.
This can be done by using the following, which disables concatenation and gzip'ing of static resources.
define( 'CONCATENATE_SCRIPTS', false );