Multiscale Electrophysiology Format version 2.1
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Multiscale Electrophysiology File Format (v2.1).pdf
Multiscale Electrophysiology File Format (v2.2).pdf


Multiscale Electrophysiology Format version 2.1

Copyright 2012, Mayo Foundation, Rochester MN. All rights reserved Written by Ben Brinkmann, Matt Stead, and Dan Crepeau usage and modification of this source code is governed by the Apache 2.0 license Licensed under the Apache License, Version 2.0 (the "License"); you may not use this file except in compliance with the License. You may obtain a copy of the License at

Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License.

Thanks to all who acknowledge the Mayo Systems Electrophysiology Laboratory, Rochester, MN in academic publications of their work facilitated by this software. (

Additional information about the MEF file format is available via academic publications:

Brinkmann BH, Bower MR, Stengel KA, Worrell GA, Stead M. “Multiscale electrophysiology format: an open-source electrophysiology format using data compression, encryption, and cyclic redundancy check”. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:7083-7086.
Brinkmann BH, Bower MR, Stengel KA, Worrell GA, Stead M. “Large-scale electrophysiology: acquisition, compression, encryption, and storage of big data”. J Neurosci Methods. 2009;180(1):185-192.
Bower MR, Stead M, Brinkmann BH, Dufendach K, Worrell GA. “Metadata and Annotations for Multi-scale Electrophysiological Data.” Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:2811–2814.