We are currently in the process of updating the RDFLib documentation with common use cases and usage patterns with working with RDFLib processing in conjunction with pyld's JSON-LD processing.
See RDFLib/rdflib#2823
Please comment there if there are common patterns you would like to see added to the documentation.
A resolution to this issue ticket could be to add a link to the documentation page in RDFLib once it's up.