During the set up, it states to save both: 1. 'export WORKON_HOME=~/Envs' >> ~/.bash_profile 2. 'source /usr/local/bin/virtualenvwrapper.sh' >> ~/.bash_profile to the bash_profile file at virtualenv & virtualenvwrapper stage but it did not work for me on Linux. I found that by saving them to bashrc file worked for me.