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Downloading the databases is a required step if your input is a filtered shotgun sequencing metagenome file (fastq, fastq.gz, fasta, or fasta.gz format) and you don't have your own reference database.
NOTE: The seqSight config file will be updated to point to this location for the default database. If you move this database, please use the "seqSight_config" command to update the default location of this database.