AMR Situation & Policy Reviews

2022

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext

2023

2024:

WHO bacterial priority pathogens list, 2024: Bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance https://www.who.int/publications/i/item/9789240093461

Laura Piddock on Advancing global antibiotic research, development and access

https://www.nature.com/articles/s41591-024-03218-w

GBD 2021 Antimicrobial Resistance Collaborators on analysis of global AMR burden (1990-2021) with forecasts to 2050

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01867-1/fulltext

Achieving sustainable access to antibiotics is more than just a last mile challenge

https://www.nature.com/articles/s41579-024-01083-5

Navigation

Introduction

Overview

Background and Target Validation

Screening Efforts

DSI Poised Fragment Library

Initial MurD Hits

Initial MurE Hits

Pocket binding site

The Atomwise Library

XChem EcMurE Atomwise library 1

SPR with the Atomwise library

Enamine Kinase Inhibitors (MurD/MurE)

ZINC/Enamine Docking

Generative Modelling Competition

Generative Modelling Competition: SPR results

Fragment Hit to Lead Efforts

MurD Round 1

MurE Round 1

Dual Inhibitors

AZ Efflux & Multi-targeting Series

Modification of Existing Inhibitors

Microbiology Assays of WYH Compounds

Biochemical Assays of WYH compounds

Crystallography

Project Resources and Data

OSA ELN Collections

CompChem Tools

PDB and Fragalysis

Sources of Data

Assay Protocols

Project Meetings

Newsletters and Other Outreach

Project Support

Acknowledgements and Who's Involved