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neuroimage-analysis

These scripts provide visualizations of brain scan data in MATLAB.

We analyze both fMRI [functional magnetic resonance imaging] data and utilize DTI [diffusion tensor imaging] methods.

current dataset: https://openneuro.org/datasets/ds000114/versions/1.0.2

paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC3641991/pdf/2047-217X-2-6.pdf

downloading the data: Use the shell script ds000114-1.0.2.sh which includes curl commands. Change the permissions to make it executable:

chmod +x ds000114-1.0.2.sh

Then run

./ds000114-1.0.2.sh

to download the dataset which may take a few minutes.

fMRI animations:

  • script = ds000114_basic_animations_statistics.m
  • loads both functional (func) and anatomical data (anat)
  • produces three animations as .gif files [temporal functional, spatial functional, spatial anatomical]
  • computes basic statistics
  • outputs a time series for a given voxel

DTI visualizations:

  • guide: https://www.diffusion-imaging.com/
  • script = ds000114_dti_examples.m
  • computes four DTI values [AD, RD, MD, FA] for fixed voxel in ds000114-1.0.2
  • computes [AD, RD, MD, FA] for across slices
  • displays and saves resulting 2d images

activation examples

  • script = ds000114_activation_examples.m
  • set paths for the dataset and GitHub project folder
  • define canonical HRF (double gamma) for modeling brain response
  • loop over subjects to load fMRI data and event timing
  • build design matrix by convolving condition onsets with HRF
  • fit voxelwise GLM to estimate beta maps for each condition
  • save PNGs showing all conditions for each subject and the group average

paths: Ensure your path is set appropriately (change the username). Place the data downloaded from the shell script in the GitHub repository root directory.

  • data downloaded from shell script: '/Users/<your-username-here>/Documents/GitHub/neuroimage-analysis/ds000114-1.0.2'

datasets:

future brain imaging methods:

  • MRA [magnetic resonance angiography]

future topics:

  • multi-modal studies [combining different data types; genetic, questionaire data, GWAS etc.]
  • neurodegenerative bases for disorders such as bipolar, schizophrenia [e.g. myelination]

articles:

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analysis of brain scans in MATLAB using techniques like DTI [diffusion tensor imaging]

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