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Releases: ABowlOfEleven/genomeforge

GenomeForge v0.1.2

11 Jun 12:39
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v0.1.2
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GenomeForge v0.1.1

10 Jun 19:43
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v0.1.1
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GenomeForge v0.1.1

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GenomeForge v0.1.0

10 Jun 06:32
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v0.1.0
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GenomeForge v0.1.0

The first release of GenomeForge — a local, native genomics workbench that runs entirely on your machine. Import your DNA and explore it down to the variant, design plasmids and CRISPR edits, and model polygenic risk, with nothing leaving your computer.

Research and educational use only — not medical advice.

Highlights

Genome browser & variant explorer

  • Import 23andMe / AncestryDNA raw data, VCF, FASTA, or GenBank.
  • Variants drawn as lollipops coloured by ClinVar significance, annotated against ClinVar, gnomAD, and dbSNP (via MyVariant.info).
  • One-click quick-jumps to common health SNPs (APOE, Factor V Leiden, MTHFR, …).
  • Filterable variant table and a per-variant deep dive with links to dbSNP, ClinVar, GWAS Catalog, MedlinePlus, and NCBI Gene — plus a live PubMed search.

Plasmid designer

  • Circular and linear maps, restriction-site mapping with unique-cutter highlighting, ORF detection and translation, primer Tm / GC, and a digest / cloning preview with a mini gel.

CRISPR studio

  • SpCas9 guide design with a real Doench 2014 on-target model, CFD off-target scoring (against the target or a loaded reference genome), NHEJ / HDR edit simulation, and an AAV cargo planner.

Phenotype & risk

  • Polygenic scores from the PGS Catalog applied to your genome, with coverage and an ancestry caveat, plus the Mendelian / ClinVar findings that can matter on their own.

Built for every level — a Beginner / Intermediate / Expert dropdown retunes the whole interface, and every section has a short built-in tutorial.

Download & install

Windows

  • GenomeForge-0.1.0-x64.msi — per-user installer (no admin needed); adds a Start-menu shortcut.
  • GenomeForge-0.1.0-x64-portable.exe — single self-contained executable, no install.

Linux

  • GenomeForge-0.1.0-x86_64-linux.tar.gz — extract and run ./GenomeForge (glibc-based distro; Wayland or X11).
  • GenomeForge-0.1.0-x86_64.flatpak — flatpak install --user GenomeForge-0.1.0-x86_64.flatpak, then flatpak run io.github.abowlofeleven.GenomeForge. File access is portal-mediated, so no broad filesystem permission is needed.

macOS

  • GenomeForge-0.1.0-macos-universal.dmg — universal (Intel + Apple Silicon). The build is unsigned, so on first launch right-click the app and choose Open (or run xattr -dr com.apple.quarantine GenomeForge.app).

Privacy

Your raw genotypes never leave your machine — only variant identifiers (rsIDs) and genomic regions are sent to public annotation APIs, and an offline toggle renders entirely from the local cache.

Known limitations

  • The macOS build is ad-hoc-signed only, so Gatekeeper will warn until it is notarized.
  • The Flatpak uses a network build (ideal as a downloadable bundle, but not yet Flathub-submittable).
  • Polygenic-score percentiles assume a European-ancestry reference and transfer poorly to other ancestries — this is surfaced in the app.

Build from source

GenomeForge is a pure-Rust workspace (egui / eframe). cargo run -p gx-app to launch; per-platform packaging is documented in BUILD.md.

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