BCRRepertoireEngine

Model B-cell receptor repertoires with somatic hypermutation, affinity maturation, and germline gene usage analysis.

Features

• Somatic hypermutation rate estimation across clonotypes
• Affinity maturation trajectory modeling
• Germline V/D/J gene usage frequency analysis
• Isotype distribution (IgG, IgM, IgA, IgE) quantification
• Memory vs naive B-cell subset classification

Results

30 donors × 5,000 clonotypes; Mean SHM=0.060 mut/bp; IgG=45%; Memory=37%

Usage

pip install numpy scipy matplotlib
python bcr_repertoire_engine.py

Tags

bcr-repertoire, somatic-hypermutation, affinity-maturation, germline-usage, antibody-diversity