EnhancerPromoterEngine

Activity-by-Contact (ABC) Model for Enhancer-Gene Linking

A pure-Python implementation of the ABC model for predicting enhancer-gene regulatory interactions.

Features

• Enhancer activity scoring (H3K27ac × ATAC signal)
• Contact frequency from Hi-C distance decay model (power law)
• ABC score: Activity × Contact / Σ(Activity × Contact)
• Enhancer-gene assignment (top ABC score per gene)
• Differential enhancer activity between cell types

Results

• 1000 candidate enhancers, 500 genes, 2 cell types
• Mean activity: A=25.45, B=6.72
• Max ABC score: 0.882
• Mean enhancer-gene distance: 100.4 kb
• Cell-type-specific enhancers: A=200, B=200

Usage

pip install numpy scipy matplotlib
python enhancer_promoter_engine.py

Tags

enhancer promoter cis-regulatory abc-model e-p-interaction chip-seq