MutationalSignatureEngine

Mutational signature extraction engine using NMF decomposition of trinucleotide contexts with COSMIC SBS signature attribution.

Features

• 96-channel trinucleotide mutation context matrix construction
• NMF-based de novo signature extraction with rank selection
• COSMIC SBS signature matching and attribution
• Cophenetic correlation coefficient for stability assessment
• Per-tumor signature exposure quantification

Results

100 tumors × 96 contexts; Optimal rank=5; Cophenetic=0.849; Recon error=0.010

Usage

pip install numpy scipy matplotlib
python mutational_signature_engine.py

Tags

mutational-signatures, sbs, cosmic-signatures, nmf-decomposition, trinucleotide-context