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mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.WordSection1 {page:WordSection1;} --> </style> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="1026"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--> </head> <body lang=EN-US link="#0563C1" vlink="#954F72" style='tab-interval:.5in'> <div class=WordSection1> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Model files in the NEURON simulation environment (v8.0) from the paper<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span class=GramE><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'>" Circadian</span></b></span><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1"<o:p></o:p></span></b></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>by John P. McCauley, Maurice A. <span class=SpellE>Petroccione</span>, <span class=SpellE>Lianna</span> Y. D</span><span style='font-size:11.0pt; font-family:Symbol;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri;mso-hansi-theme-font:minor-latin;mso-bidi-font-family: Calibri;mso-bidi-theme-font:minor-latin;mso-char-type:symbol;mso-symbol-font-family: Symbol'><span style='mso-char-type:symbol;mso-symbol-font-family:Symbol'>¢</span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'>Brant, Gabrielle C. Todd, <span class=SpellE>Nurat</span> <span class=SpellE>Affinnih</span>, Justin J. <span class=SpellE>Wisnoski</span>, <span class=SpellE>Shergil</span> <span class=SpellE>Zahid</span>, <span class=SpellE>Swasti</span> Shree, <span class=SpellE>Alioscka</span> A. Sousa, Rose M. De Guzman, Rosanna <span class=SpellE>Migliore</span>, Alexey <span class=SpellE>Brazhe</span>, Richard D. <span class=SpellE>Leapman</span>, Alexander <span class=SpellE>Khmaladze</span>, Alexey <span class=SpellE>Semyanov</span>, Damian G. <span class=SpellE>Zuloaga</span>, Michele <span class=SpellE>Migliore</span> and Annalisa <span class=SpellE>Scimemi</span>. <o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Cell Reports 2020<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Usage:<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Auto-launch from <span class=SpellE>ModelDB</span> or:<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Compile the mod files with <span class=SpellE>mknrndll</span> (<span class=SpellE>mswin</span> or graphical mac) or<o:p></o:p></span></p> <p class=MsoPlainText><span class=SpellE><span class=GramE><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'>nrnivmodl</span></span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> (<span class=SpellE>unix</span>/<span class=SpellE>linux</span>)). Start the simulation by (<span class=SpellE>unix</span>/<span class=SpellE>linux</span>) typing<o:p></o:p></span></p> <p class=MsoPlainText><span class=GramE><span style='font-size:11.0pt; font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin'>on</span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> the command line:<o:p></o:p></span></p> <p class=MsoPlainText><span class=SpellE><span class=GramE><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'>nrngui</span></span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> <span class=SpellE>mosinit.hoc</span><o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span class=GramE><span style='font-size:11.0pt; font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin'>or</span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> (mac <span class=SpellE>os</span> x) drag and dropping the <span class=SpellE>mosinit.hoc</span> file on the <span class=SpellE>nrngui</span><o:p></o:p></span></p> <p class=MsoPlainText><span class=GramE><span style='font-size:11.0pt; font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-hansi-theme-font: minor-latin;mso-bidi-theme-font:minor-latin'>icon</span></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'> or (<span class=SpellE>mswin</span>) double clicking on the <span class=SpellE>mosinit.hoc</span> file.<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>After selecting the option corresponding to the modulation of the NMDA and AMPA receptor properties, simulation will reproduce the temporal summation of composite glutamatergic EPSPs at the stimulation frequency of 10 Hz (as in fig. 6C of the paper).<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Example: clicking on <span class=SpellE><i style='mso-bidi-font-style: normal'>Astrocites</i></span><i style='mso-bidi-font-style:normal'> only</i> on the initial window should produce the following graph:<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText align=center style='text-align:center'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin; mso-no-proof:yes'><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Immagine_x0020_1" o:spid="_x0000_i1025" type="#_x0000_t75" style='width:438.5pt;height:231pt;visibility:visible;mso-wrap-style:square'> <v:imagedata src="readme_file/image001.png" o:title=""/> </v:shape><![endif]--><![if !vml]><img width=585 height=308 src="readme_file/image002.png" v:shapes="Immagine_x0020_1"><![endif]></span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font:minor-latin'><o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Questions on how to use this model <span class=GramE>should be directed</span> to rosanna.migliore@cnr.it<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>The morphology <span class=GramE>is uploaded</span> to the neuromorpho.org database (<a href="http://www.neuromorpho.org">www.neuromorpho.org</a>).<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>An interactive <i style='mso-bidi-font-style:normal'>live paper</i> page is available in the Brain Simulation Platform of the Human Brain Project<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>(https://humanbrainproject.github.io/hbp-bsp-live-papers/<span class=GramE>index.htm )</span><o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>Access to this resource requires free user registration at https://www.humanbrainproject.eu/en/hbp-platforms/getting-access/ <o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'>All datasets generated during and/or analyzed during the current study are also available on Open Science Framework (https://bit.ly/3jsJXrO).<o:p></o:p></span></p> <p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri",sans-serif; mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-theme-font: minor-latin'><o:p> </o:p></span></p> </div> </body> </html>