ModelDrug

Antimalarial drug modeling

There are three different ways of modeling antimalarial pharmacokinetics and pharmacodynamics (PK/PD) in OpenMalaria:

1. A simple success/failure model in which drug Treatment either clears all infections in the host (treatSimple option in health system / intervention component) or does nothing. This can be extended to include a prophylactic effect which simply removes all new infections for a configurable number of steps in the future.
2. Clearing infections via above method then using Pre-erythrocytic vaccines to probabilistically prevent reinfection (this allows a slightly more realistic prophylactic effect than the above).
3. Explicit pharmacokinetic and pharmacodynamic modeling of drugs (treatPKPD option in health system / intervention component), linked to a dynamic model of parasite densities in the course of an infection.