Negative effect amplifiers, particularly for health boost and occasionally jump boost have been used frequently in PGM maps over the years. However, Mojang removed negative effect amplifiers in 1.20.5. It may make sense to handle these in some way, perhaps by converting a negatively amplified health boost effects to an equivalent max-health kit.
Handling jump boost is less straightforward; historically negatively amplified jump boost effects have been used to temporarily disable fall damage and/or attempt to restrict jumping.