ProteinRisk

A protein risk assessment tool that analyzes amino acid sequences for harmful structural motifs and validates their claimed organism of origin.

Features

• Organism Verification: Validates whether a protein sequence likely originates from the claimed organism
• Harmful Motif Detection: Identifies dangerous structural patterns including:
  • HEXXH groups (metalloprotease motifs)
  • Pore-forming protein domains
• Two-Stage Analysis:
  1. Organism authenticity check
  2. Structural risk assessment

Quick Start

# Install dependencies
cd probe_code
pip install -r requirements.txt

# Run the web application
cd ..
flask --app webapp run

The app will be available at http://localhost:5000

How It Works

Submit a protein sequence and organism origin through the web interface. The system performs two validation stages:

1. Stage 1: Verifies the sequence matches the organism's expected signature patterns
2. Stage 2: Scans for known harmful protein structures

Returns a comprehensive risk assessment with confidence scores.

Project Structure

• webapp/: Flask web application with frontend and backend logic
• probe_code/: ML models and protein analysis utilities
  • detector_probe1.py, detector_probe2.py: Neural network models for harm detection
  • metalloprotease_sequences.py, pore_forming_sequences.py: Training data and analysis
  • Pre-trained models: probe1_model.pt, probe2_model.pt